Urolithin A shine metabolite na hanji na ellagic acid tare da tasirin antioxidant da antiproliferative; yana hana haɓakar ƙwayoyin T24 da Caco-2 tare da ƙimar IC50 na 43.9 da 49 μM, bi da bi.

Halin jiki da sinadarai na urolitin A

Urolithin A shine metabolite na biyu na fili na polyphenol na halitta ellagitannin. Binciken na baya-bayan nan ya nuna cewa urolithin A yana da mahimman ayyukan nazarin halittu, irin su anti-oxidation, anti-inflammatory, anti-tsufa, daidaita estrogen / androgen da kuma haifar da mitochondrial autophagy. Saboda haka, urolithin A yana taka muhimmiyar rawa wajen rigakafi da magance cututtuka da yawa, kamar ciwon daji, cututtukan zuciya, cutar Alzheimer, cutar Parkinson, ciwon sukari, kiba, osteoarthritis, da dai sauransu.

Tushen da halaye na tsarin urolithin

Urolithin A (UroA) da urolithin B (UroB) an fara keɓe su daga duwatsun koda na tumaki a matsayin metabolites na ellagic acid. Urolithin na halitta ba kowa bane a yanayi, amma a matsayin metabolite na ellagic tannin ko ellagic acid, an rarraba shi sosai a cikin fitsari, najasa da bile na dabbobi masu shayarwa kamar mutane, beraye, beraye, shanu da aladu. Espín et al. An gano cewa za a iya wadatar da urolithin zuwa babban taro a cikin mafitsara da gallbladder na aladun Iberian, amma babu wani abu mai mahimmanci a cikin sauran kyallen takarda kamar tsoka, mai, koda, hanta da zuciya. Nazarin gwaji a cikin mice da mutane sun gano cewa urolithin da abubuwan da suka samo asali sun wadatar a cikin nama na prostate kuma ana rarraba su a cikin ƙwayar hanji na mutum.

Urolithin yana samuwa ta hanyar ellagic acid ya rasa zoben lactone kuma a hankali ya lalata shi. Bayan ellagic acid ya rasa zoben lactone, urolithin M-5 (UroM-5) an fara samo shi. UroM-5 an dehydroxylated a wurare daban-daban don samar da dama tetrahydroxy urolithin isomers kamar urolithin D (UroD) da urolithin M-6 (UroM-6). Tetrahydroxy urolithin ya rasa ƙungiyar hydroxyl don samar da trihydroxy urolithins kamar urolithin C (UroC) da urolithin M-7 (UroM-7). Trihydroxy urolithin ya rasa wani rukunin hydroxyl don samar da dihydroxy urolithins kamar UroA da urolithin A isomer (isoUroA), kuma a ƙarshe an sami monohydroxy urolithin B (UroB). Bugu da ƙari, isoUroA ya ​​fi sauƙi don dehydroxylate don samar da UroB fiye da UroA. Garcia-Villalba et al. An yi amfani da gwaje-gwajen metabolism na in vitro na hanji na hanji don gano metabolites na ellagic acid, UroM-5, UroM-6, UroM-7, UroC, da urolithin E (UroE), yana mai tabbatarwa a karon farko cewa an samar da urolithin a ƙarƙashin aikin flora na hanji.

Urolithin A shine samfurin flora na hanji. Bayan da jikin dan Adam ya ci kayan lambu da 'ya'yan itatuwa irin su rumman, berries da goro, kwayoyin cuta na hanji da kuma phenolic antioxidants masu arziki a cikin 'ya'yan itatuwa da kayan marmari na sama suna mayar da martani don samar da urolithin A. A cikin 'yan shekarun nan, wasu bincike na asali sun nuna cewa urolithin A yana taimakawa. mitochondrial yaduwa kuma yana ƙarfafa aikinsa, don haka inganta lafiyar kwayar halitta, kuma tasirin yana da mahimmanci a cikin tsokoki, kwakwalwa, haɗin gwiwa da sauran sassa.

Ƙarin fa'idodin urolithin A: asarar nauyi da kitsen visceral

Bugu da ƙari, urolitin A yana taimakawa rage nauyi. Wani gwaji na dabba a cikin 2020 ya nuna cewa ƙungiyar masu binciken sun ciyar da beraye masu kiba ta hanyoyi 4: abinci na yau da kullun, abinci mai mai yawa, abincin mai mai mai yawa wanda aka ƙara da urolithin A bayan makonni 10, da abinci mai mai mai yawa wanda aka ƙara da urolithin B bayan makonni 10. Sakamakon ƙarshe shine ƙungiyoyin biyu na berayen masu kiba da aka haɓaka tare da urolithin sun sami raguwa mai yawa a cikin nauyi da kitsen visceral.